With shares of Boeing (NYSE:BA) trading around $134, is BA an OUTPERFORM, WAIT AND SEE, or STAY AWAY? Let�� analyze the stock with the relevant sections of our CHEAT SHEET investing framework:T = Trends for a Stock’s Movement
Boeing is an aerospace company. It focuses primarily on engineering, information technology, research and development, test and evaluation, technology strategy development, environmental remediation management, and intellectual property management. The company operates in five segments: Commercial Airplanes, Boeing Military Aircraft, Network & Space Systems, Global Services & Support, and Boeing Capital Corp.
Boeing released its annual forecast Tuesday and said that commercial jet buyers will look to capital markets to provide more financing in 2014, as the value of jet sales is rising by about 7.7 percent and they need to fund an anticipated $112 billion in jet deliveries next year. While capital markets accounted for just 3 percent of total jet financing in 2009, that number rose to 14 percent this year, and will jump to 22 percent in 2014.
Hot Prefered Companies To Invest In 2015: Globe Specialty Metals Inc.(GSM)
Globe Specialty Metals, Inc., together with its subsidiaries, produces and sells silicon metal and silicon-based alloys in North America, Europe, South America, and Asia. The company primarily offers silicon metal that is used as a raw material for silicone compounds, aluminum, and polysilicon. It also produces silicon-based alloys, such as ferrosilicon; magnesium-ferrosilicon-based alloys known as nodularizers; ferrosilicon-based alloys known as inoculants; calcium silicon alloys; and cored-wire silicon-based alloy products, as well as carbon electrodes, silica fume, and fines. The silicon-based alloy products are used as raw materials for steel, automotive components, and ductile iron. In addition, the company processes and supplies specialty metallurgical coal to other silicon and silicon-based alloy producers. Its customers include silicone chemical, aluminum, and steel manufacturers; auto companies and their suppliers; ductile iron foundries; manufacturers of photovol taic solar cells and computer chips; and concrete producers. The company was formerly known as International Metal Enterprises, Inc. and changed its name to Globe Specialty Metals, Inc. in November 2006. Globe Specialty Metals, Inc. was incorporated in 2004 and is headquartered in New York, New York.Advisors' Opinion:
- [By Marc Bastow]
Silicon metals and alloys producer Globe Specialty Metals (GSM) raised its quarterly dividend 7.1% to 7.5 cents per share, payable March 12 to shareholders of record as of Feb. 26.
GSM Dividend Yield: 1.65%
Best Rising Stocks To Watch For 2014: Brookfield Office Properties Inc. (BPO)
Brookfield Properties Corporation is a publicly owned real estate investment firm. The firm engages in the ownership, development, and management of premier commercial properties. It also provides ancillary real estate service businesses, such as tenant service and amenities. The firm invests in the real estate markets of the United States with a focus on North American cities, including New York, Boston, Washington, D.C., Toronto, Calgary, Denver, and Minneapolis. It primarily invests in properties and development sites predominantly office buildings. The firm operates as a subsidiary of Brookfield Asset Management Inc. It was formerly known as Carena-Bancorp Holdings, Inc. and changed its name to Le Holding Carena-Bancorp Inc. in 1978. The company further changed its name to Carena-Bancorp, Inc. in 1985; to Carena Developments Limited in 1989; and to Brookfield Properties Corporation in 1996. Brookfield Properties was founded in 1923 and is based in New York, New York wi th an additional office in Toronto, CanadaAdvisors' Opinion:
- [By Jake L'Ecuyer]
Shares of Brookfield Office Properties (NYSE: BPO) got a boost, shooting up 13.45 percent to $19.02 after Brookfield Property Partners (NYSE: BPY) proposed to acquire Brookfield Office Properties for $19.34 per share.
- [By Victor Selva]
Xerox Corporation (XRX), with a market capitalization of $13.11 billion, is among the largest companies in the global document markets. It is a provider of business process and document management. The company is a Business Process Outsourcing (BPO) company engaged in managing transaction processes.
Best Rising Stocks To Watch For 2014: PPG Industries Inc.(PPG)
PPG Industries, Inc. manufactures and supplies protective and decorative coatings. The company offers coatings products for automotive and commercial transport/fleet repair and refurbishing, specialty coatings for signs, and light industrial coatings; and sealants, coatings, and technical cleaners/transparencies for commercial, military, regional jet, general aviation aircraft, and transparent armor for military land vehicles. It also provides coatings and finishes for the protection of metals and structures to metal fabricators, heavy duty maintenance contractors, and manufacturers of ships, bridges, rail cars, and shipping containers; and coatings to painting and maintenance contractors. In addition, PPG sells industrial and automotive coatings to manufacturing companies; adhesives and sealants for the automotive industry; metal pretreatments and related chemicals; and coatings and inks for aerosol, food, and beverage containers. Further, it supplies lenses, sunlenses, a nd optical lens materials; amorphous precipitated silicas for tire and battery separator markets; and Teslin substrate used in radio frequency identification tags and labels, e-passports, drivers? licenses, and identification cards applications. Additionally, PPG offers chlor-alkali and derivative products, such as chlorine, caustic soda, vinyl chloride monomer, chlorinated solvents, calcium hypochlorite, ethylene dichloride, hydrochloric acid, and phosgene derivatives to chemical processing, rubber and plastics, paper, minerals, metals, and water treatment industries. It also produces flat glass and continuous-strand fiber glass for commercial and residential construction, wind energy, energy infrastructure, transportation, and electronics industries. PPG sells its products through company-owned stores, home centers, paint dealers, and independent distributors, as well as directly to customers worldwide. The company was founded in 1883 and is headquartered in Pittsburgh, Pe nnsylvania.Advisors' Opinion:
- [By Anna Prior]
PPG Industries Inc.(PPG) agreed to acquire architectural and industrial coatings company Consorcio Comex SA for $2.3 billion. PPG Chief Executive Charles E. Bunch said the acquisition is complementary to the paint and coatings maker’s business.
- [By Rich Duprey]
Privately held specialty-coatings producer Deft will be acquired by PPG Industries (NYSE: PPG ) for an undisclosed sum.�
Deft's primary business is supplying structural primers and military topcoats to the North American aviation industry, as well as architectural and industrial coatings, though they comprise much�smaller parts of its business.
- [By Monica Gerson]
PPG Industries (NYSE: PPG) is projected to report its Q1 earnings at $1.87 per share on revenue of $3.63 billion.
Chipotle Mexican Grill (NYSE: CMG) is expected to report its Q1 earnings at $2.86 per share on revenue of $873.83 million.
- [By Dan Caplinger]
Players throughout the paint industry have seen their prospects rise in light of the housing recovery. In its most recent report, Sherwin-Williams (NYSE: SHW ) posted record profits and sales for its first quarter, as net income rose 17%. Sherwin projected that revenue growth would likely accelerate during the rest of the year. Fellow competitor PPG Industries (NYSE: PPG ) also managed to top earnings estimates in its quarterly report last month, although its sales didn't produce the increase that analysts had expected to see.
Best Rising Stocks To Watch For 2014: Natural Resource Partners LP (NRP)
Natural Resource Partners L.P. is a limited partnership. The Company is engaged principally in the business of owning, managing and leasing mineral properties in the United States. It owns coal reserves in the three United States coal-producing regions: Appalachia, the Illinois Basin and the Western United States, as well as lignite reserves in the Gulf Coast region. The Company is engaged in the ownership and leasing of mineral properties and related transportation and processing infrastructure. As of December 31, 2011, the Company owned or controlled approximately 2.3 billion tons of proven and probable coal reserves and it also owned approximately 380 million tons of aggregate reserves in a number of states across the country. During the year ended December 31, 2011, its lessees produced 49.2 million tons of coal from its properties. In addition, the Company�� lessees produced 49.2 million tons of coal from its properties. The Company�� operations are conducted through, and its operating assets are owned by, its subsidiaries. The Company owns its subsidiaries through a wholly owned operating company, NRP (Operating) LLC. NRP (GP) LP, which is its general partner, which conducts its business and manages its operations. Because its general partner is a limited partnership, its general partner, GP Natural Resource Partners LLC, conducts its business and operations. Robertson Coal Management LLC owns all of the membership interest in GP Natural Resource Partners LLC. In addition to its preparation plants, the Company owns coal handling and transportation infrastructure in West Virginia, Ohio and Illinois. In February 2011, it acquired approximately 500 acres of mineral and surface rights related to limestone reserves on the Tennessee River near Paducah, Kentucky. In March 2011, it acquired approximately 500 acres of mineral and surface rights related to limestone reserves in Cleveland, Tennessee near Chattanooga. In July 2011, it acquired approximately 44,000 acres of coal reserves and coal bed met! hane located in Pennsylvania and Illinois. In February 2012, the Company acquired coal reserves at the Deer Run mine near Hillsboro, Illinois and approximately 9,500 net mineral acres located in the Mississippian Lime oil play in Northern Oklahoma. In March 2012, the Company acquired the rail loadout, associated infrastructure assets and a contractual overriding royalty interest on certain tonnage at the Sugar Camp mine near Benton, Illinois. In May 2012, the Company completed the acquisition of approximately 19,200 net mineral acres in the Mississippian Lime oil play in North Central Oklahoma.
The Beaver Creek property is located in Grant and Tucker Counties, West Virginia. During 2011, 2.4million tons were produced from this property. The Company leases this property to Mettiki Coal, LLC, which is a subsidiary of Alliance Resource Partners L.P. Coal is produced from an underground longwall mine. It is transported by truck to a preparation plant operated by the lessee. Coal is shipped primarily by truck to the Mount Storm power plant of Dominion Power and to various export customers. During 2011, 366,000 tons were produced from Allegany County. The Company leases this property to Vindex Energy, a subsidiary of Arch Coal. Coal from this property is produced from a surface mine. The raw coal is trucked to the Warrior plant of Allegheny Energy. During 2011, 283,000 tons were produced from Area F property. It leases this property to Carter Roag, a subsidiary of Metinvest. Coal from this property is produced from an underground mine. The raw coal is trucked to a preparation plant operated by the lessee. Coal is shipped via rail to domestic metallurgical customers and exported for use by Metinvest.
The VICC/Alpha property is located in Wise, Dickenson, Russell and Buchanan Counties, Virginia. During 2011, 4.9 million tons were produced from this property. It primarily leases this property to a subsidiary of Alpha Natu! ral Resou! rces. Production comes from both underground and surface mines and is trucked to one of four preparation plants. Coal is shipped through both the CSX and Norfolk Southern railroads to utility and metallurgical customers. Customers include American Electric Power, Southern Company, Tennessee Valley Authority, VEPCO and the United States Steel and to various export metallurgical customers. The Lynch property is located in Harlan and Letcher Counties, Kentucky. During 2011, 4.8 million tons were produced from this property. The Company primarily leases the property to a subsidiary of Massey Energy. Production comes from both underground and surface mines. Coal is transported by truck to a preparation plant on the property and is shipped primarily on the CSX railroad to utility customers, such as Georgia Power and Orlando Utilities.
The Dingess-Rum property is located in Logan, Clay and Nicholas Counties, West Virginia. This property is leased to subsidiaries of Massey Energy and Patriot Coal. During 2011, 2.8 million tons were produced from the property. Coal is shipped through the CSX railroad to steam customers, such as American Electric Power, Dayton Power and Light, Detroit Edison and to various export metallurgical customers.
The VICC/Kentucky Land property is located primarily in Perry, Leslie and Pike Counties, Kentucky. During 2011, 2.5 million tons were produced from this property. Coal is produced from a number of lessees from both underground and surface mines. Coal is shipped primarily by truck but also on the CSX and Norfolk Southern railroads to customers, such as Southern Company, Tennessee Valley Authority and American Electric Power. The Lone Mountain property is located in Harlan County, Kentucky. During 2011, 2.1 million tons were produced from this property. The Company leases the property to a subsidiary of Arch Coal, Inc. Production comes from underground mines and is transported primarily by beltline to a preparation plant on adjacent property and shipped o! n the Nor! folk Southern or CSX railroads to utility customers, such as Georgia Power and the Tennessee Valley Authority.
The D.D. Shepard property is located in Boone County, West Virginia. This property is primarily leased to a subsidiary of Patriot Coal Corp. During 2011, two million tons were produced from the property. Both steam and metallurgical coal are produced by the lessees from underground and surface mines. Coal is transported from the mines through belt or truck to preparation plants on the property. Coal is shipped through the CSX railroad to various domestic and export metallurgical customers. The Pardee property is located in Letcher County, Kentucky and Wise County Virginia. During 2011, 1.8 million tons were produced from this property. It leases the property to a subsidiary of Arch Coal, Inc. Production comes from underground and surface mines and is transported by truck or beltline to a preparation plant on the property and shipped primarily on the Norfolk Southern railroad to utility customers, such as Georgia Power and the Tennessee Valley Authority and domestic, and export metallurgical customers, such as Algoma Steel and Arcelor.
The Kingston property is located in Fayette and Raleigh Counties, West Virginia. This property is leased to a subsidiary of Alpha Natural Resources. During 2011, 1.5 million tons were produced from the property. Both steam and metallurgical coal are produced from underground and surface mines and has been historically transported by belt or truck to a preparation plant on the property or shipped raw. Coal is shipped via both the CSX railroad and by truck to barges to steam customers and various export metallurgical customers.
The BLC properties are located in Kentucky and Tennessee. During 2011, 1.2 million tons were produced from these properties. The Company leases these properties to a number of operators, including Appolo Fuels Inc., Bell County Coal Corporation and Kopper-Glo Fuels. Prod! uction co! mes from both underground and surface mines and is trucked to preparation plants and loading facilities operated by its lessees. Coal is transported by truck and is shipped through both CSX and Norfolk Southern railroads to utility and industrial customers. Customers include Southern Company, South Carolina Electric & Gas, and numerous medium and small industrial customers. The Oak Grove property is located in Jefferson County, Alabama. During 2011, 470,000 tons were produced from this property. The Company leases the property to a subsidiary of Cliffs Natural Resources, Inc. Production comes from an underground mine and is transported primarily by beltline to a preparation plant. The metallurgical coal is then shipped through railroad and barge to both domestic and export customers.
The Williamson property is located in Franklin and Williamson Counties, Illinois. The property is under lease to an affiliate of the Cline Group. During 2011, 6.8 million tons were mined on the property. This production is from a longwall mine. Production is shipped primarily through CN railroad to customers, such as Duke and to various export customers. The Macoupin property is located in Macoupin County, Illinois. The property is under lease to an affiliate of the Cline Group. During 2011, 1.8 tons were shipped from the property. Production is from an underground mine and is shipped through the Norfolk Southern or Union Pacific railroads or by barge to customers, such as Western KY Energy and other midwest utilities or loaded into barges for shipment to export customers. The Sato property is located in Jackson County, Illinois. During 2011, 363,000 tons were produced from the property. The property is under lease to Knight Hawk Coal LLC, an independent coal producer. As of December 31, 2011, production was from a surface mine, and coal was shipped by truck and railroad to various midwest and southeast utilities.
Northern Powder River Basin
The Western Ener! gy proper! ty is located in Rosebud and Treasure Counties, Montana. During 2011, 2.7 million tons were produced from the Company�� property. A subsidiary of Westmoreland Coal Company has two coal leases on the property. Coal is produced by surface dragline mining, and the coal is transported by either truck or beltline to the four-unit 2,200-megawatt Colstrip generation station located at the mine mouth and by the Burlington Northern Santa Fe railroad to Minnesota Power. A small amount of coal is transported by truck to other customers.
As of December 31, 2011, BRP had acquired, in several stages, approximately 8.8 million mineral acres in 29 states from International Paper. As of December 31, 2011, BRP held 78 revenue generating leases. BRP�� assets include approximately 300,000 gross acres of oil and gas mineral rights in Louisiana, of which over 72,000 acres were under lease, as of December 31, 2011. In addition, BRP holds a gross production royalty interest on approximately 23,000 mineral acres under lease in Louisiana. The remaining oil and gas mineral acreage in Louisiana is not leased. As of December 31, 2011, BRP owned nearly 246,000 gross mineral acres of primarily lignite coal rights in the Gulf Coast region, of which approximately 5,000 acres are leased under three separate leases in Louisiana and Alabama. In addition to the coal rights, BRP held aggregate reserves, including limestone, granite, clay, and sand and gravel reserves, under lease in six states. As of December 31, 2011, other mineral rights held by BRP included coalbed methane rights in four Gulf Coast states, metals rights in three states, approximately 450,000 acres of water rights in East Texas, geothermal rights and royalty interests in the Gulf Coast and Pacific Northwest and carbon sequestration rights primarily in the Gulf Coast region.Advisors' Opinion:
- [By Robert Rapier]
Rounding out the bottom five were�OCI Partners�(NYSE: OCIP), a methanol and ammonia producer (-24 percent YTD),�Natural Resource Partners�(NYSE: NRP), another coal producer (-19 percent), and�Eagle Rock Energy Partners�(NASDAQ: EROC), an oil and gas production partnership (-17 percent).
- [By Robert Rapier]
The National Association of Publicly Traded Partnerships (NAPTP) lists five MLPs in the category ��atural Resources – Coal,��although two of the five are Alliance Holdings (NYSE: AHGP) and its operating affiliate, Alliance Resource Partners (NYSE: ARLP). The other three are Natural Resource Partners (NYSE: NRP), Rhino Resource Partners (NYSE: RNO), and Oxford Resource Partners (NYSE: OXF).
- [By Rich Duprey]
With steam coal prices continuing to be weak due to the inroads made by natural gas, Natural Resource Partners (NYSE: NRP ) has decided if you can't beat 'em, join 'em. It announced Monday it is buying producing�oil and gas�properties located in the Williston Basin of North Dakota and Montana from�Abraxas Petroleum (NASDAQ: AXAS ) for $35.3 million in cash.
- [By Tyler Crowe]
In the energy world, it's never much of a surprise when an oil company picks up natural gas assets or vice versa. But a coal company getting into the oil business? Now that's a rarity. This week, Natural Resources Partners (NYSE: NRP ) �did just that. The company announced that it's taking a working interest in some of Abraxas Petroleums (NASDAQ: AXAS ) assets in the Bakken. While the $35 million purchase was not that large, it's a rare case where a coal company branches out into other natural resources.�
Best Rising Stocks To Watch For 2014: ARM Holdings PLC (ARMH)
ARM Holdings plc (ARM), incorporated on October 16, 1990, designs microprocessors, physical intellectual property (IP) and related technology and software, and sells development tools. As of December 31, 2012, the Company operated in three business segments: the Processor Division (PD), the Physical IP Division (PIPD) and the System Design Division (SDD). ARM licenses and sells its technology and products to international electronics companies, which in turn manufacture, markets and sells microprocessors, application-specific integrated circuits (ASICs) and application-specific standard processors (ASSPs) based on ARM�� technology to systems companies for incorporation into a range of end products. It also licenses and sells development tools directly to systems companies and provides support services to its licensees, systems companies and other systems designers.
ARM processor architecture and physical IP is used in embedded microprocessor applications, including cellular phones, digital televisions, mobile computers and personal computer peripherals, smart cards and microcontrollers. ARM�� principal geographic markets are Europe, the United States and Asia Pacific. ARM�� product offering includes microprocessor Cores: RISC microprocessor cores, including specific functions, such as video and graphics IP and on-chip fabric IP; embedded software; physical IP; development tools, and support and maintenance services.
The PD encompasses those resources that are centered on microprocessor cores, including specific functions, such as graphics IP, fabric IP, embedded software IP and configurable digital signal processing (DSP) IP. Service revenues consist of design consulting services and revenues from support, maintenance and training.
Physical IP Division
The PIPD is focused on building blocks for translation of a circuit design into actual silicon. During the year ended December 31, 2012, the Company�� total av! erage PIPD headcount was 557. ARM is a provider of physical IP components for the design and manufacture of integrated circuits, including systems-on-chip (SoCs). ARM Artisan physical IP products include embedded memory, standard cell and input/output components. Artisan physical IP also includes a limited portfolio of analog and mixed-signal products. ARM�� physical IP components are developed for a range of process geometries ranging from 20 nanometer - 250 nanometer. ARM licenses its products to customers for the design and manufacture of integrated circuits used in complex, high-volume applications, such as portable computing devices, communication systems, cellular phones, microcontrollers, consumer multimedia products, automotive electronics, personal computers and workstations and many others.
ARM�� embedded memory components include random access memories, read only memories and register files. These memories are provided in the form of a configurable memory compiler, which allows the customer to generate the appropriate configuration for the given application. ARM�� memory components include many configurable features, such as power-down modes, low-voltage data retention and fully static operation, as well as different transistor options to trade off performance and power. In addition, ARM�� memory components include built-in test interfaces that support the industry test methodologies and tools. ARM memory components also offer redundant storage elements.
ARM�� memory components are designed to enable the chip designer maximum flexibility to achieve the optimum power, performance, and density trade-off. ARM offers standard cell components that are optimized for high performance, high density or ultra high density. ARM logic products deliver optimal performance, power and area when building ARM Processors, Graphics, Video and Fabric IP along with general SoC subsystem implementation. ARM delivers physical interface for a range of DDR SDRAM (double-data rate s! ynchronou! s dynamic random-access memory) applications ranging from mission critical applications to low-power memory sub-systems. Silicon on Insulator (SOI) products is an alternative methodology to traditional semiconductor fabrication techniques.
System Design Division
The SDD is focused on the tools and models used to create and debug software and system-on-chip (SoC) designs. ARM�� software development tools help a software design engineer deliver products right the first time. Engineers use these tools in the design and deployment of code, from applications running on open operating systems right through to low-level firmware. The ARM Development Studio is a hardware components that allow the software designer to connect to a real target system and control the system for the purposes of finding errors in the software. The ARM DSTREAM unit allows the software developer to control the software running on the prototype product and examine the internal state of the prototype product. ARM Development Boards are ideal systems for prototyping ARM-based products. The ARM Microcontroller Development Kit supports ARM-based microcontrollers and 8051-based microcontrollers from companies, such as Analog Devices, Atmel, Freescale, Fujitsu, NXP, Samsung, Sharp, STMicroelectronics, Texas Instruments and Toshiba. The ARM Microcontroller Development Kit is used by developers who are building products and writing software using standard off-the-shelf microcontrollers.
The ARM Microprocessor Families
ARM architecture processors offers a range of performance options in the ARM7 family, ARM9 family, ARM11 family, ARM Cortex family and ARM SecurCore family. The ARM architecture gives systems designers a choice of processor cores at different performance/price points. The ARM7 offers 32-bit architecture capable of operating from 8/16-bit memory on an 8/16-bit bus through the implementation of the Thumb instruction set. The ARM9 family consists of a range of microprocessors in ! the 150-2! 50MHz range. Each processor has been designed for a specific application or function, such as an application processor for a feature phone or running a wireless fidelity (WiFi) protocol stack. The ARM9 family consists of a range of microprocessors in the 150-250 megahertz range. The ARM11 family consists of a range of microprocessors in the 300-600 megahertz range. ARM Cortex family is ARM�� family of processor cores based on version 7 of the ARM Architecture. The family is split into three series: A Series, A Series and M Series.Advisors' Opinion:
- [By Tony Reading]
LONDON -- I've always balked at�ARM Holding's (LSE: ARM ) (NASDAQ: ARMH ) 's massive price-to-earnings ratio. Even after a 10% fall from last month's high, the shares are trading at 46 times forecast earnings. Some say the pull-back is a buying opportunity.
Best Rising Stocks To Watch For 2014: Inovio Pharmaceuticals Inc (INO)
Inovio Pharmaceuticals, Inc., incorporated on June 29, 1983, is engaged in the development of a new generation of vaccines, called synthetic vaccines, focused on cancers and infectious diseases. The Company's SynCon technology enables the design of universal vaccines capable of providing cross-protection against existing or changing strains of pathogens, such as influenza and human immunodeficiency virus (HIV). The Company's electroporation delivery technology uses brief, controlled electrical pulses to increase cellular uptake of the vaccine. Its clinical programs include cervical dysplasia (therapeutic), avian influenza (preventive), prostate cancer (therapeutic), leukemia (therapeutic), hepatitis C virus (HCV) and HIV vaccines. It is advancing preclinical research and clinical development for a universal seasonal/pandemic influenza vaccine, as well as preclinical work for other products, including malaria and prostate cancer vaccines. Its partners and collaborators include University of Pennsylvania, Drexel University, National Microbiology Laboratory of the Public Health Agency of Canada, Program for Appropriate Technology in Health/Malaria Vaccine Initiative (PATH/MVI), National Institute of Allergy and Infectious Diseases (NIAID), Merck, ChronTech, University of Southampton, United States Military HIV Research Program (USMHRP), the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) and HIV Vaccines Trial Network (HVTN). As of December 31, 2011 it owned 16.1% interest in VGX Int��.
The Company�� synthetic vaccine platform consists of its SynCon vaccine design process and electroporation delivery technology. It has developed a preclinical and clinical stage pipeline of vaccines. The Company�� synthetic vaccines are designed to prevent a disease (prophylactic vaccines) or treat an existing disease (therapeutic vaccines). Its synthetic vaccine consists of a deoxyribonucleic acid (DNA) plasmid encoding a selected antigen! (s), which is introduced into cells of humans or animals with the purpose of evoking an immune response to the encoded antigen. The Company�� synthetic vaccines are designed to generate specific antibody and/or T-cell responses.
The Company�� SynCon technology provides processes that employ bioinformatics, which combine extensive genetic data and sophisticated algorithms. Its design process uses the genetic make-up of a common antigen(s) from multiple strains of a virus within a viral sub-type or taxonomic group (family) of pathogens, such as HIV, hepatitis C virus (HCV), human papillomavirus (HPV), influenza and other diseases to synthetically create a new antigen for the desired pathogen target that does not exist in nature. Its synthetic vaccine candidates are being delivered into cells of the body using its electroporation (EP) DNA delivery technology.
Cancer Synthetic Vaccines
The Company has two broad types of cancer vaccines: preventive (or prophylactic) vaccines, which are intended to prevent cancer from developing in healthy people, and treatment (or therapeutic) vaccines, which are intended to treat an existing cancer by strengthening the body�� natural defenses against the cancer. Two types of cancer preventive vaccines are available in the United States. The United States Food and Drug Administration (the FDA) has approved two vaccines, Gardasil and Cervarix that protect against infection by the two types of HPV-types 16 and 18-that cause approximately 70% of all cases of cervical cancer worldwide. In addition, Gardasil protects against infection by two additional HPV types, 6 and 11, which are responsible for about 90% of all cases of genital warts in males and females but do not cause cervical cancer.
Cervarix manufactured by GlaxoSmithKline, is composed of virus-like particles (VLPs) made with proteins from HPV types 16 and 18. Cervarix is approved for use in females��ages 10 to 25 for the prevention of cervical cancer caused by! HPV type! s 16 and 18. Gardasil manufactured by Merck, is approved for use in females for the prevention of cervical cancer, and some vulvar and vaginal cancers, caused by HPV types 16 and 18 and for use in males and females for the prevention of genital warts caused by HPV types 6 and 11. The vaccine is approved for these uses in females and males ages 9 to 26. The FDA has also approved a cancer preventive vaccine that protects against hepatitis B virus (HBV) infection.
Inovio�� VGX-3100 is designed to raise immune responses against the E6 and E7 genes of HPV types 16 and 18 that are present in both pre-cancerous and cancerous cells transformed by these HPV types. E6 and E7 are oncogenes that play an integral role in transforming HPV-infected cells into cancerous cells. In March 2011, it initiated a randomized, double-blind Phase II study of VGX-3100 delivered using the CELLECTRA intramuscular electroporation device in women with HPV Type 16 or 18 and diagnosed with, but not yet treated for, cervical intraepithelial neoplasia (CIN) 2/3. The study is designed to enroll 148 subjects. In January 2011, it announced the publication of a scientific paper in the journal Human Vaccines detailing potent immune responses in a preclinical study of its SynCon vaccine for prostate cancer targeting two antigens, prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA).
In January 2011, the Company announced the regulatory approval of a Phase II clinical trial (WIN Trial) to treat leukemia utilizing its new ELGEN 1000 automated vaccine delivery device. The single dose level, Phase II study, called WT1 immunity via DNA fusion gene vaccination in haematological malignancies by intramuscular injection followed by intramuscular electroporation. Cancer Vaccines encodes for hTERT, an antigen related to non-small cell lung, breast and prostate cancers. The vaccine is delivered using its electroporation delivery technology.
Infectious Disease Synthetic VaccinesIn Marc! h 2011, the Company announced the initiation of a follow-on open label, single dose Phase II clinical study in collaboration with ChronTech of the ChronVac-C HCV DNA vaccine delivered using its electroporation technology in treatment naive HCV infected individuals. Its HIV vaccines consist of candidates for HIV prevention, as well as therapy or treatment. PENNVAX-B is designed to target HIV clade B (most commonly found in the United States, North America, Australia and the European Union (EU). PENNVAX-G is designed to target HIV clades A, C and D, which are more commonly found in Asia, Africa, Russia and South America. This Phase I clinical study of PENNVAX-B (HVTN-080) vaccinated 48 healthy, HIV-negative volunteers to assess safety and levels of immune responses generated by Inovio�� PENNVAX-B vaccine delivered with its CELLECTRA electroporation device. PENNVAX-B is a SynCon vaccine that targets HIV gag, pol, and env proteins.
The Company�� VGX-3400X targets H5N1. The vaccine consists of three distinct DNA plasmids coded for a consensus hemagglutinin (HA) antigen derived from different H5N1 virus strains; a consensus neuraminidase (NA) antigen derived from different N1 sequences; and a consensus nucleoprotein (NP) fused to a small portion of the m2 protein (m2E) based on a broader cross-section of influenza viruses in addition to H5N1 and H1N1. Conventional vaccines are strain-specific and have limited ability to protect against genetic shifts in the influenza strains they target. They are therefore modified annually in anticipation of the next flu season�� new strain(s). It is focused on developing DNA-based influenza vaccines able to provide broad protection against known as well as newly emerging, unknown seasonal and pandemic influenza strains.
VGX Animal Health, Inc. (VGX AH), a majority-owned subsidiary, has licensed LifeTide, a plasmid-based growth hormone releasing hormone (GHRH) technology for swine. LifeTide is one of onl! y four DN! A-based treatments approved for use in animals and is the only DNA-based agent delivered using electroporation that has been granted marketing approval (Australia). VGX AH is also developing a GHRH-based treatment for cancer and anemia in dogs and cats. It is developing a synthetic vaccine for foot-and-mouth disease (FMD) administered by its vaccine delivery technology. The FMD virus is one of the most infectious diseases affecting farm animals, including cattle, swine, sheep and goats, and is a serious threat to global food safety.
The Company competes with Crucell N.V, Sanofi-Aventis, Novartis, Inc., GlaxoSmithKline plc, Merck, Pfizer, AstraZeneca, Inc., Novartis, Inc., MedImmune and CSL.Advisors' Opinion:
- [By Jake L'Ecuyer]
Equities Trading DOWN
Shares of Inovio Pharmaceuticals (NYSE: INO) were down on Friday's session, falling 13.28 percent to $2.488 despite seemingly little news on the company.
- [By Roberto Pedone]
Another biotechnology player that insiders are jumping into here is Inovio Pharmaceuticals (INO), which discovers, develops, and develops synthetic vaccines and immune therapies focusing on cancers and infectious diseases. Insiders are buying this stock into notable weakness, since shares are off by 17.4% so far in 2014.
Inovio Pharmaceuticals has a market cap of $578 million and an enterprise value of $415 million. This stock trades at a premium valuation, with a price-to-sales of 30.15 and a price-to-book of 4.30. Its estimated growth rate for this year is 56.9%, and for next year it's pegged at -43.5%. This is a cash-rich company, since the total cash position on its balance sheet is $108.86 million and its total debt is zero.
The CEO just bought 250,000 shares, or about $2.26 million worth of stock, at $9.05 per share.
From a technical perspective, INO is currently trending below both its 50-day and 200-day moving averages, which is bearish. This stock has been downtrending badly for the last few weeks, with shares moving lower from its high of $14.20 to its recent low of $8.60 a share. During that downtrend, shares of INO have been consistently making lower highs and lower lows, which is bearish technical price action. Shares of INO have now started to explode higher off that $8.60 low and it's quickly approaching a big breakout trade.
If you're in the bull camp on INO, then I would look for long-biased trades as long as this stock is trending above Wednesday's intraday low of $8.92 or above that recent low of $8.60 and then once it breaks out above both its 50-day at $10.11 and its 200-day at $10.24 a share with high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average action of 1.87 million shares. If that breakout hits soon, then INO will set up to re-test or possibly take out its next major overhead resistance levels at $11 to $11.50, or even $12 to $12.5
- [By Jake L'Ecuyer]
Inovio Pharmaceuticals (NYSE: INO) was also up, gaining 10.53 percent to $3.57 after the company received the ��est Theraputic Vaccine��award at the World Vaccine Congress after the close Wednesday.
- [By MONEYMORNING]
Inovio Zooms: We recommended biotech Inovio Inc. (NYSE: INO) at 71 cents a share back on Feb. 1, 2013, and have re-recommended it a number of times since. With their 15.2% gain yesterday, the shares are now at $3.71, up 414% from where we first told you about them - and we believe there's more to come. In fact, we'll be bringing you an interesting update on this company very soon. Inovio is one of 24 recommendations that have doubled or better since we launched Private Briefing back in August 2011.
Best Rising Stocks To Watch For 2014: Astea International Inc.(ATEA)
Astea International Inc. develops, markets, and supports service management software solutions worldwide. The company licenses its solutions to various companies that sell and service equipment, and/or sell and deliver professional services. It offers Astea Alliance suite that includes series of applications to address lead generation, project quotation, service and billing, and asset retirement services. Astea International Inc. integrates and optimizes business processes for campaigns, call center, depot repair, field service, logistics, projects, and sales and order processing applications; provides mobile, dynamic scheduling, portals, and business intelligence solutions; and offers infrastructure tools and services. It also provides FieldCentrix Enterprise suite, a service management solution that runs on various mobile devices, such as handheld computers, laptops and PCs, and pocket PC devices, as well as integrates with CRM and ERP applications; and features a Web-ba sed customer self-service portal, workforce optimization capabilities, and equipment-centric functionality. In addition, the company offers consulting, implementation, training, and maintenance services. Its solutions are used in information technology, medical devices and diagnostic systems, industrial controls and instrumentation, retail systems, office automation, imaging systems, facilities management, telecommunications, and other industries with equipment sales and service requirements. Astea International Inc. markets its products through a network of direct and indirect sales and services offices; and through distributors consisting of value-added resellers, system integrators, and sales agents, as well as original equipment manufacturer partners. The company was formerly known as Applied System Technologies, Inc. and changed its name to Astea International Inc. in 1992. Astea International Inc. was founded in 1979 and is headquartered in Horsham, Pennsylvania.Advisors' Opinion:
- [By Lisa Levin]
Astea International (NASDAQ: ATEA) shares dropped 18.60% to $2.10 after the company reported a Q2 loss of $0.23 per share.
NQ Mobile (NYSE: NQ) fell 11.39% to $5.68 after the company announced management changes.